Ablevia's team envisions a future where the targeted removal of unwanted and disease-causing antibodies no longer imposes inefficient and stressful restrictions. Our mission is to offer a therapeutic principle for removing disease-causing and drug-neutralizing antibodies specifically and rapidly for the benefit of our partners, customers and patients.
Certain types of antibodies can be harmful instead of protecting us from infections: Drug-neutralizing antibodies pose a problem in the application of a wide range of modern biologics or viral vectors, whereas self-attacking autoantibodies can trigger autoimmune conditions.
Ablevia has developed a proprietary platform technology enabling the efficient and selective sequestration of harmful antibodies by a new class of infusible biological therapeutics. It enables rapid removal of unwanted and harmful antibodies in a selective manner.
Our antibody depleting compounds are readily adapted to target disease-causing and unwanted antibodies in rare diseases and conditions whith unmet clinical needs.
Founded in 2018 at the Vienna BioCenter Campus, Ablevia focuses on preclinical research and development. We are reaching out for programs with strong partners in need of addressing undesired antibodies in preclinical and clinical development.
Anti-drug-antibodies (ADAs) and neutralizing antibodies (NAbs) against biologics
Repeated administration of biologics can elicit immune responses against the administered drug. The formation of NAbs against a biologic drug leads to changes in its clearance rate, and distribution within the body. This can affect the effectivity of the drug.
Neutralizing antibodies against viral gene therapy vectors
NAbs against viral gene therapy vectors can occur even before the first or repeated administration of a viral vector. Ablevia's SADC technology target such pre-existing or induced neutralizing antibodies for those patients who would otherwise not be eligible for gene therapy if they carry neutralizing antibodies.
Reduction of drug efficacy
To enhance solubility, circulation time and tissue distribution and to reduce immunogenicity, peptide and protein drugs can be coupled to polyethylene glycol (PEG). However pre-existing or drug-induced antibodies against PEG shields can be the cause for the "accelerated blood clearance (ABC)" phenomenon, leading to a reduction of drug efficacy.
Substitution and replacement therapies
Repeated administration of biologics that are recognized as "foreign" by the patients' immune system, often cause an antibody response that leads to drug clearance and inhibition. This fundamental problem mainly affects patients that are in need of regular enzyme or factor replacement therapies, including rare genetic diseases or metabolic conditions.
The SADC technology offers individual solutions for removing unwanted and harmful antibodies rapidly and selectively. SADCs facilitate the targeting of NAbs against new biologics with foreign structures, against protein and peptide drugs in replacement therapies, or against gene therapy and oncolytic viral vectors. Ablevia’s compounds can be adapted to well-defined disease-causing autoantibodies in the emerging field of autoimmune conditions, such as some neuroimmunological diseases. Do not hesitate to get in touch with us about your ideas!
Get in touch
Want to take a closer look at our strategies how to remove harmful antibodies while sparing the protective pool of immunoglobulins? We are happy to explain the SADC technology for the removal of harmful and undesired antibodies.
By precisely defining your target autoantibodies or neutralizing antibodies together, we will set the ground for developing specifically adapted SADC leads, that are shaped to target harmful or unwanted autoantibodies.
Co-development & licensing
Ablevia offers co-development and licensing of newly developed SADCs for further preclinical and clinical development. Contact us for further information about our business model.